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pentobarbital boosts toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. CYP3A4 inducers may well raise the metabolism of ifosfamide to its Energetic alkylating metabolites.pentobarbital will lessen the level or impact of dasatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/